Yes, but only if the request would force the business to produce speech (rather than merely to serve customers with certain identities or viewpoints) against the owner's religious beliefs.
Example: A business whose owner's religious beliefs are against gay couples should be able to refuse to put "Happy gay birthday" on a cake but shouldn't be able to refuse to put merely "Happy birthday" and shouldn't be able to refuse to sell a cake lacking pro-gay messages to a gay couple.
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